Halt sexual action and have health care help at once if you can get signs for instance upper body pain, dizziness, or nausea for the duration of sexual intercourse.
50 mg er den mest foreskrevne dosen og den beste startdosen for de fleste førstegangsbrukere. Det betyr at dosen er lett å justere hvis den ikke fungerer for deg eller du opplever bivirkninger.
Another medicines may well change the blood levels of sildenafil. Convey to your healthcare supplier about all medicines that you choose to choose or have just lately taken.
Viagra og Sildenafil er i hovedsak den samme medisinen. Hovedforskjellen er hvem som produserer dem.
Sildenafil is a strong and selective inhibitor of cGMP-precise phosphodiesterase sort five (PDE5), that's liable for degradation of cGMP in the corpus cavernosum. The molecular framework of sildenafil is analogous to that of cGMP and acts for a competitive binding agent of PDE5 inside the corpus cavernosum, causing much more cGMP and enhanced penile reaction to sexual stimulation.
The indicate regular point out volume of distribution (Vss) for sildenafil is one hundred and five L, indicating distribution to the tissues. Sildenafil and its main circulating N-desmethyl metabolite are each roughly 96% certain to plasma proteins. Protein binding is independent of total drug concentrations.
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet eller uregelmessige hjerteslag/hjertebank. Les pakningen og pakningsvedlegget nøye fileør bruk.
Will not share sildenafil with Others, whether or not they've a similar problem as you. It might harm them.
If you're taking sildenafil Once you try to eat a superior-Fats food, for instance a burger and fries, it could just take more time to begin Doing work.
NO then activates the enzyme guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP), making clean muscle mass leisure from the corpus cavernosum and allowing inflow of blood.
The security of VIAGRA is unfamiliar in patients with bleeding Diseases and sufferers with Lively peptic ulceration.
Equivalent values for pharmacokinetic parameters were witnessed here in typical volunteers and in the individual inhabitants, using a populace pharmacokinetic solution.
[75] A person author notes that Even though the effect of Viagra is simply restricted to penile blood vessels, advertisements routinely use imagery of couples hugging, smiling and dancing, While using the author professing that pharmaceutical providers were deceptive in the use of these kinds of commercials.[seventy six]
At doses previously mentioned the encouraged dose vary, adverse reactions were being comparable to Those people in-depth in Desk 1 below but generally were being described far more often.